Ignorance means ignorance of our own Buddha-nature.

Ignorance means ignorance of our own Buddha-nature. In this respect, we are as ignorant as a beggar with a precious jewel in his hand who, not recognizing how valuable it is, simply throws it away.

It is because of ignorance that we are the slaves of our thoughts and cannot tell right from wrong. It is because of ignorance that we are blind to the law of cause and effect and refuse to believe that every action has a result. It is because of ignorance that we cannot accept the existence of past and future lives. It is because of ignorance that we have no confidence in the beneficial results of praying to the Three Jewels. It is because of ignorance that we do not recognize the truth of the Dharma.

Ignorance is at the very root of the eighty-four thousand negative emotions, for as long as we fail to see that the true nature of everything is voidness, we insist on believing that things really exist; and this is the source of all deluded perceptions and all negative thoughts...

~ Dilgo Khyentse Rinpoche
'Heart Treasure of the Enlightened Ones'